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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are usually focused on the practical aspects of the study design, including recruitment and consent as well as adherence to the use of commonly available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed different investigators and had participants from various geographical areas. This type of heterogeneity is essential for pragmatic trials to be valid and helps to reduce bias in the results. However excessive heterogeneity could cause problems with the design of the trial.

Pragmatic Play, one of the biggest players on the live casino market, provides various classic table games, including Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta offer an authentic gaming experience for its customers, as well as a wide range of virtual betting options. The company also offers a variety of game shows that make online gambling exciting and interactive. Some of these shows are telecast live and others are hosted by famous personalities from the field.

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Pragmatic Play is a new player in the online casino industry however, it has established itself through its mobile-friendly slot machines. Their games are optimized for mobile devices and are powered by HTML5 technology. They're also endorsed by trusted gaming authorities to ensure fairness and transparency. This is a positive sign for players, as it means that the games are checked and verified to ensure that the results of every round are random and unbiased.

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Legality

Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. The software is available on mobile devices as well as in various languages. It has established itself as one of the top gaming platforms in the casino industry despite its relative infancy. The most recent releases include Wolves 5 reel video slot with a healthful RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

The goal of pragmatic trials is to replicate real-life scenarios and to achieve the highest level of validity externally. They are usually requested by practitioners and policy makers to aid in their decision-making. They also provide a useful method to determine the causal relationship between the intervention and its effects. However, they should not be used to replace the need for explanation studies.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can replace explanatory tests or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials, which inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study which includes recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.