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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are usually focused on practical aspects of the study design, such as the recruitment process and consent in adherence, as well as the use of routinely available equipment.

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Pragmatic Software, a software firm offers a range of casino games to online gambling platforms. Pragmatic's iGaming solutions are used by the top operators and casinos with a physical location. The company provides front-end site design tools, analysis tools and marketing, promotions security, payment systems, customer service and bug reporting. Additionally, the company offers its users a safe environment that features high-quality graphics and gaming.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and had participants from different geographic areas. This type of heterogeneity is essential for practical trials to be valid and helps to reduce the chance of bias in the results. However, too much heterogeneity can lead to problems with the design of the trial.

Pragmatic Play is one of the biggest players on the live casino market, provides various classic table games, including Blackjack and Roulette. The company's live studios in Romania and Malta provide a genuine gaming experience for its customers, as well as an extensive selection of virtual betting options. The company also has several game shows that make online gambling enjoyable and engaging. Some of these shows are broadcast live, while others are hosted by famous personalities from the field.

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Pragmatic Play is renowned for its top-quality games and also for providing an outstanding user experience. The software is available on mobile devices as well as in various languages. Despite its relative youth it has established itself as a premier casino gaming platform. Wolves is one of its latest releases which is a five-reel slot machine that has a high RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. Usually, they are ordered by policymakers and practitioners to help guide their decisions. They are also a good method of determining the causality between the intervention and its effects. However, they should not be used as a substitute for explanatory trials.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis as well as pragmatic trials, which guide the policy and practice of. They also proposed the framework for pragmatic trials, called PRECIS.2 This tool was designed to define the elements of a practical trial that include recruitment, design and delivery of the intervention, and monitoring.

The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these studies were conducted in primary-care settings.